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Yoshiaki Tsuji

Associate Professor

Research Interests

  • Signaling pathways leading to transcriptional activation of antioxidant genes under oxidative and genotoxic stress
  • Chromatin remodeling and gene regulation
  • Disorder of iron homeostasis and neurodegeneration
  • Mitochondrial oxidative stress

Areas of Research: oxidative stress, iron homeostasis, chromatin remodeling, gene regulation, cell signaling – visit Yoshi Tsuji Lab Homepage

Selected Publications

P. D. Ray, B-W Huang, and Y. Tsuji  “Reactive Oxygen Species (ROS) Homeostasis and Redox Regulation in Cellular Signaling”                          Cell. Signal., 24: 981-990 (2012)        full text

K. Hailemariam, K. Iwasaki, B-W. Huang, K. Sakamoto, and Y. Tsuji  “Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress”  J. Cell Sci., 123: 3863-3871 (2010)      full text

K. Sakamoto, B-W. Huang, K. Iwasaki, K. Hailemariam, J. Ninomiya-Tsuji and Y. Tsuji  “Regulation of Genotoxic Stress Response by Homeodomain-interacting Protein Kinase 2 through Phosphorylation of Cyclic AMP Response Element-binding Protein at Serine 271″                                                          Mol. Biol. Cell  21: 2966-2974 (2010)    full text

K. Sakamoto, K. Iwasaki, H. Sugiyama and Y. Tsuji  “Role of the Tumor Suppressor PTEN in Antioxidant Responsive Element-mediated Transcription and Associated Histone Modifications.    Mol. Biol. Cell  20: 1606-1617 (2009)     full text

F. Zhang, W. Wang, Y. Tsuji, S.V. Torti and F.M. Torti  “Post-transcriptional Modulation of Iron Homeostasis during p53-dependent Growth Arrest”            J. Biol. Chem., 283: 33911-33918 (2008)    full text

E.L. MacKenzie, P. D. Ray and Y. Tsuji  “Role and Regulation of Ferritin H in Rotenone-mediated Mitochodrial Oxidative Stress”   Free Radic. Biol. Med., 44: 1762-1771 (2008)    full text

E.L. MacKenzie and Y. Tsuji  “Elevated Intracellular Calcium Increases Ferritin H Expression through an NFAT-independent Posttranscriptional Mechanism Involving mRNA Stabilization” Biochem. J.,  411: 107-113 (2008)     full text

E.L. MacKenzie, K. Iwasaki and Y. Tsuji  “Intracellular Iron Transport and Storage: From Molecular Mechanisms to Health Implications”            Antioxid. Redox Signaling, 10: 997-1030 (2008)         full text

K. Iwasaki, K. Hailemariam and Y. Tsuji  “Protein Inhibitor of Activated STAT3 (PIAS3) Interacts with Activating Transcription Factor 1 (ATF1) and Regulates an Antioxidant Responsive Element of the Human Ferritin H Gene”                 J. Biol. Chem., 282: 22335-22343 (2007)     full text

K. Iwasaki, E. L. MacKenzie, K. Hailemariam, K. Sakamoto and Y. Tsuji  “Hemin-mediated Regulation of an Antioxidant Responsive Element of the Human Ferritin H Gene and Role of Ref-1 during Erythroid Differentiation of K562 Cells”  Mol. Cell. Biol., 26: 2845-2856 (2006)     full text

J. E.Jennings-Gee, Y. Tsuji, E. C. Pietsch, E. Moran, J.S. Mymryk, F. M. Torti and S. V. Torti  “Coordinate Inhibition of Cytokine-mediated Induction of Ferritin H, Manganese Superoxide Dismutase, and Interleukin-6 by the Adenovirus E1A Oncogene”   J. Biol. Chem., 281: 16428-16435 (2006)          full text

Y. Tsuji   “JunD Activates Transcription of the Human Ferritin H Gene through an Antioxidant Response Element during Oxidative Stress”  Oncogene, 24: 7567-7578 (2005)   full text